Our studies show that glyphosate acts as a dis- ruptor of mammalian cytochrome P450 aro- matase activity from concentrations 100 times lower than the recommended use in agricul- ture; this is noticeable on human placental cells after only 18 hr, and it can also affect aro- matase gene expression. It also partially dis- rupts the ubiquitous reductase activity but at higher concentrations. Its effects are allowed and amplified by at least 0.02% of the adju- vants present in Roundup, known to facilitate cell penetration, and this should be carefully taken into account in pesticide evaluation. The dilution of glyphosate in Roundup for- mulation may multiply its endocrine effect. Roundup may be thus considered as a poten- tial endocrine disruptor. Moreover, at higher doses still below the classical agricultural dilutions, its toxicity on placental cells could induce some reproduction problems.
Inga kommentarer:
Skicka en kommentar